Paracetamol, Diclofenac Sodium and Caffeine Capsules
Andydol Forte
Andydol Forte
Description:
Andydol Forte is a triple-action analgesic capsule combining Paracetamol (500 mg), Diclofenac Sodium (50 mg), and Caffeine (30 mg). This formulation offers enhanced pain relief, especially for inflammation-related pain, with the added stimulant effect of caffeine, which boosts the efficacy of analgesics.
Mechanism Of Action:
- Paracetamol: Provides central analgesic and antipyretic action.
- Diclofenac Sodium: Inhibits COX enzymes and reduces inflammation and pain.
- Caffeine (Anhydrous): Enhances the effectiveness of analgesics and provides mild stimulation to reduce fatigue commonly associated with pain.
Indication:
- Mild to moderate pain associated with inflammation
- Musculoskeletal disorders, headaches, backaches
- Postoperative pain, dental pain, menstrual pain
- Joint and muscle pain due to sprains and strains
Dosage and Administration:
- Adults and children above 12 years: 1 capsule two or three times daily
- Not recommended for children under 12 years
- Follow physician’s directions for personalized dosage
Possible side effects include:
- GI discomfort, nausea, ulceration, or bleeding
- Tachycardia, flushing, high blood pressure
- Hypersensitivity reactions: rash, itching
- Renal effects, changes in hearing or vision
- Liver toxicity with prolonged use
- Withdrawal effects (due to caffeine): headache, anxiety, muscle tension
Contraindications:
- Allergy to NSAIDs, aspirin, or any formulation ingredient
- Active peptic ulcer or severe renal dysfunction
- Pregnancy (due to caffeine content)
- Severe cardiovascular disorders
Use with caution in:
- Liver or kidney impairment
- Elderly patients or those with heart failure
- Patients with asthma, anemia, or lupus
- Avoid abrupt discontinuation due to caffeine withdrawal
- Avoid use in combination with other NSAIDs, corticosteroids, anticoagulants, methotrexate, or lithium
Drug Interactions:
- May increase bleeding risk when used with anticoagulants or corticosteroids
- Can interact with antidiabetics, antihypertensives, and immunosuppressants
- Paracetamol absorption is increased by metoclopramide
- Probenecid reduces clearance, increasing paracetamol levels
